Biography
My research addresses clinical questions by studying human subjects or patients. I collaborate with other faculty in the department on my research and provide expertise in the following areas: data analysis and statistics; mathematical modeling; data acquisition programming; human studies; respiratory physiology.
My research involvement has included multiple different projects:
• Accuracy of pulse oximetry, including determination of methemoglobin, carboxyhemoglobin, and the accuracy of cerebral oximetry.
• Organ transplantation and efforts to improve the quality of cadaveric organs.
• Acute normovolemic hemodilution to study the tolerance of acute anemia, as a way to examine red cell transfusion thresholds. Additionally, we have used this model to study other issues in transfusion, including TRALI.
• The utility of somatosensory and motor evoked potential, which are used in major spine surgery to assess the integrity of spinal cord function.
• The physiology of breathholding and drug-induced apnea.
• High altitude physiology
• Clinical effects of neuromuscular blockade
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
American Board of Anesthesiology
Clinical Expertise
Kidney Transplantation
Liver Transplantation
Pancreas Transplantation
Program Affiliations
- Department of Anesthesia and Perioperative Care
- Department of Surgery, Division of Transplantation
In the News
Research Interests
Hypoxic ventilatory drive at altitude
Apnea with remifentanil and propofol
Transfusion Related Acute Lung Injury
Neuromonitoring in Spine Anesthesia
Pulse oximeter accuracy
Physiology of acute anemia
Predictors of kidney and liver donor organ function
View Research Profile at UCSF Clinical & Translational Science Institute
Publications
- Acute severe isovolemic anemia impairs cognitive function and memory in humans.| | PubMed
- Fatigue during acute isovolemic anemiain healthy, resting humans.| | PubMed
- Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1).| | PubMed
- Tidal volume, PaCO2, and lung injury.| | PubMed
- Human cardiovascular and metabolic response to acute, severe isovolemic anemia.| | PubMed
- Interactive effects of pH and temperature on N-methyl-D-aspartate receptor activity in rat cortical brain slices.| | PubMed
- Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema.| | PubMed
- Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema.| | PubMed
- Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia.| | PubMed
- Hypoxic ventilatory response predicts the extent of maximal breath-holds in man.| | PubMed