Biography
My research addresses clinical questions by studying human subjects or patients. I collaborate with other faculty in the department on my research and provide expertise in the following areas: data analysis and statistics; mathematical modeling; data acquisition programming; human studies; respiratory physiology.
My research involvement has included multiple different projects:
• Accuracy of pulse oximetry, including determination of methemoglobin, carboxyhemoglobin, and the accuracy of cerebral oximetry.
• Organ transplantation and efforts to improve the quality of cadaveric organs.
• Acute normovolemic hemodilution to study the tolerance of acute anemia, as a way to examine red cell transfusion thresholds. Additionally, we have used this model to study other issues in transfusion, including TRALI.
• The utility of somatosensory and motor evoked potential, which are used in major spine surgery to assess the integrity of spinal cord function.
• The physiology of breathholding and drug-induced apnea.
• High altitude physiology
• Clinical effects of neuromuscular blockade
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
American Board of Anesthesiology
Clinical Expertise
Kidney Transplantation
Liver Transplantation
Pancreas Transplantation
Program Affiliations
- Department of Anesthesia and Perioperative Care
- Department of Surgery, Division of Transplantation
In the News
Research Interests
Hypoxic ventilatory drive at altitude
Apnea with remifentanil and propofol
Transfusion Related Acute Lung Injury
Neuromonitoring in Spine Anesthesia
Pulse oximeter accuracy
Physiology of acute anemia
Predictors of kidney and liver donor organ function
View Research Profile at UCSF Clinical & Translational Science Institute
Publications
- Progressive suppression of motor evoked potentials during general anesthesia: the phenomenon of "anesthetic fade".| | PubMed
- No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.| | PubMed
- Acute isovolemic anemia does not impair peripheral or central nerve conduction.| | PubMed
- Heart rate increases linearly in response to acute isovolemic anemia.| | PubMed
- Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia.| | PubMed
- Productivity versus availability as a measure of faculty clinical responsibility.| | PubMed
- Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat.| | PubMed
- Hemoglobin desaturation after succinylcholine-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers.| | PubMed
- Subcutaneous perfusion and oxygen during acute severe isovolemic hemodilution in healthy volunteers.| | PubMed
- Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans.| | PubMed