University of California San Francisco

Yaron Gesthalter 759
Yaron B. Gesthalter, MD

Assistant Professor of Medicine

Interventional Pulmonary Medicine

Division of Pulmonary & Critical Care Medicine
Department of Medicine

Address

521 Parnassus Avenue, #6228
San Francisco, CA 94117
United States

Email: [email protected]
Fax: 415-476-4176

Biography

I am a Pulmonologist and Critical Care Medicine physician with sub-specialty training in Interventional Pulmonary Medicine. Using minimally invasive techniques such as endobronchial ultrasound (EBUS) and navigational bronchoscopy I diagnose and stage patients with concerning lesions. For those with symptoms related to airway obstructions (from either malignant tumor invasion or non-malignant strictures) I use various ablative techniques to relieve airway obstruction. I also treat patients with pleural disease while emphasizing outpatient care. Additionally, I attend on the UCSF pulmonary consult service and in the intensive care units.

My research relates to the early detection and prevention of lung cancer through minimally invasive ways. My research spans translational and computational approaches as well as clinical trials.

In order to schedule an appointment with Dr Gesthalter at the UCSF Interventional Pulmonary clinic please call (415)885-3882. Please bring all available images (cat scans, PET scans) on CDs at the time of consultation to facilitate care.

Clinical Expertise
• Thoracic malignancies
• Lung nodules
• Symptom management
• Diagnostic and staging procedures
• Complex pleural effusions – ultrasound, thoracentesis, chest tubes, tunneled pleural catheters, medical thoracoscopy
• Ablative bronchoscopic techniques (cryo- surgery, electrosurgery, argon plasma coagulation (APC), cryospray, photodynamic therapy)
• Advanced bronchoscopy (electromagnetic navigation bronchoscopy (EMN), endobronchial ultrasound (EBUS), rigid bronchoscopy)
• Fiducial placement for radiation therapy
• Sarcoidosis and other non-malignant lung pathologies
• Tracheal and bronchial obstructions
• Tracheal and bronchial stent placement

Research Interests
• Lung cancer diagnostics
• Bioinformatics
• Application of minimally invasive diagnostic and therapeutic techniques
• Lung cancer screening
• Smoking cessation
• Management of lung transplant related airway and pleural disease

Awards & Honors

Award Conferred By Date
Michael Stulbarg Outstanding Teacher Award University of California San Francisco 2023
Excellence in Teaching Award University of California San Francisco - Haile T. Debas Academy of Medical Educators 2019
Thoracic Oncology Assembly Abstract Scholarship American Thoracic Society 2016

Education

Institution Degree Dept or School End Date
BIDMC/MGH Harvard School of Medicine Fellowship in Interventional Pulmonary Medicine 2017
Boston University School of Medicine - Division of Computational Biomedicine Research Fellowship 2016
Boston University School of Medicine - Dept of Pulmonary & Critical Care Fellowship in Pulmonary and Critical Care 2015
Yale School of Medicine - Dept of Internal Medicine Residency 2011
Tel-Aviv University Sackler School of Medicine MD 2008
Hebrew University of Jerusalem B.Sc 2003

Clinical Expertise

Thoracic Malignancies

Lung nodules

Symptom management

Diagnostic and staging procedures

Complex pleural effusions – ultrasound, thoracentesis, chest tubes, tunneled pleural catheters, medical thoracoscopy

Ablative bronchoscopic techniques (cryo- surgery, electrosurgery, argon plasma coagulation (APC), cryospray, photodynamic therapy)

Advanced bronchoscopy [Electromagnetic navigation bronchoscopy (EMN)],Endobronchial ultrasound (EBUS), Rigid bronchoscopy

Fiducial placement for radiation therapy

Sarcoidosis and other non-malignant lung pathologies

Tracheal and bronchial obstructions

Tracheal and bronchial stent placement

Foreign Languages Spoken

Hebrew

Research Narrative

My interest is in the early diagnosis and prevention of lung cancer through screening, behavioral interventions and chemoprevention. I have used gene-expression analysis to study the molecular profiles of patients at risk for future development of lung cancer and used these profiles to understand the effects various therapies have on the pre-malignancy biology of the lungs. This holds the potential to decrease lung cancer burden by disease aversion. Additionally, I study how to apply new diagnostic technologies that might expedite patient care in a minimally invasive way.

Research Interests

Smoking cessation

Lung cancer screening

Lung cancer diagnostics

Bioinformatics

Application of minimally invasive diagnostic and therapeutic techniques

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 47
  1. NCCN Guidelines® Insights: Management of Immunotherapy-Related Toxicities, Version 2.2024.
    Thompson JA, Schneider BJ, Brahmer J, Zaid MA, Achufusi A, Armand P, Berkenstock MK, Bermas B, Braaten T, Budde LE, Chokshi S, Crees ZD, Davies M, Deng C, Gesthalter Y, Jain M, Jain P, Jallouk A, Kaffenberger BH, Khalil M, Lechner MG, Li T, Marr A, McGettigan S, McPherson J, Medina T, Mohindra NA, Olszanski AJ, Oluwole O, Patel SP, Prosek J, Reddy S, Reid P, Ryan J, Ryder M, Salman H, Santomasso B, Shofer S, Sosman JA, Wang Y, Zaha VG, Zucker S, Lyons M, Awotiwon A, Hang L| | PubMed
  2. MA02.12 UC Screen California: A Statewide Participatory Informatics Approach to Lung Cancer Screening.
    A.L. Cummings, H.I. Tupper, Y. Lin, H.B. Keshava, G. Sadigh, B.A. Glenn, D. Hamilton, R. Bastani, W. Hsu, J.W. Goldman, A. Ghasemiesfe, E.K. Tong, H. Leisy, J. Seibles, L. Rios, M. Chen, T. Yarbrough, M. Vella, B. Antonelli, Y. Gesthalter, D.R. Strong, G. Cheng, N. Patel, J. Hudson, D. Moghanaki, D.T. Cooke, A. Prosper| | UCSF Research Profile
  3. Reply to Patel and LaNou: The Missing Piece: The Intersection of Pharmacist Board Certification and Tobacco Use Disorder Treatment.
    Deepak J, Gesthalter YB, Gogineni HP, Melzer AC| | PubMed
  4. Multidisciplinary Management of Adult Patients with Chylothorax: A Consensus Statement.
    Agrawal A, Chaddha U, Shojaee S, Nadolski G, Liberman M, Lee YCG, Rahman N, Reisenauer JS, Ferguson MK, DeCamp MM, Gillaspie EA, Bedawi EO, Currie B, Feller-Kopman DJ, Desai A, Yasufuku K, Bishay V, Gesthalter Y, Grosu H, Chick JFB, Lentz R, Kolli KP, Kaufman A, Mehta RM, Desai K, Davis H, Ghori UK, Maldonado F| | PubMed
  5. Explor-A-Thora: A Novel Three-Dimensionally Printed Pleural Simulator.
    Krumm IR, Drapeau S, Kim B, Gesthalter YB, Santhosh L| | PubMed
  6. Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society/American College of Chest
    Gonzalez AV, Silvestri GA, Korevaar DA, Gesthalter YB, Almeida ND, Chen A, Gilbert CR, Illei PB, Navani N, Pasquinelli MM, Pastis NJ, Sears CR, Shojaee S, Solomon SB, Steinfort DP, Maldonado F, Rivera MP, Yarmus LB| | PubMed
  7. Education for Tobacco Use Disorder Treatment: Current State, Evidence, and Unmet Needs.
    Melzer AC, Reese ZA, Mascarhenas L, Clancy CB, Deepak J, Gogineni H, Gesthalter Y, Hart JL| | PubMed
  8. Interventional Pulmonology: Extending the Breadth of Thoracic Care.
    Gesthalter YB, Channick CL| | PubMed
  9. COMPLEX PLEURAL SPACES: THE RISKS OF REPEATED THORACENTESIS.
    BRYAN KIM, ILANA R KRUMM, YARON GESTHALTER| | UCSF Research Profile
  10. Safety and utility of indwelling pleural catheters in lung transplant recipients.
    Trindade AJ, Lentz RJ, Gannon WD, Rickman OB, Shojaee S, Vandervest K, Schwartz G, Li GW, Kumar A, Garcha PS, Seeley EJ, Gesthalter YB, Mueller S, Egan JP, DeMaio AJ, Yarmus LB, Josan ES, Pannu JK, Wayne MT, DeCardenas JL, Bacchetta MD, Maldonado F, Interventional Pulmonary Outcomes Group| | PubMed
  11. Medical Societies Must Choose Professional Meeting Locations Responsibly in a Post-Roe World.
    Lee AG, Maley J, Hibbert K, Akgün KM, Hauschildt KE, Law A, Kaminski N, Hayes M, Gesthalter Y, Bosslet GT, Santhosh L, Witkin A, Hills-Dunlap K, Çoruh B, Gershengorn HB, Hardin CC| | PubMed
  12. Real-World Perspectives and Practices for Pneumonitis/Interstitial Lung Disease Associated With Trastuzumab Deruxtecan Use in Human Epidermal Growth Factor Receptor 2-Expressing Metastatic Breast Cancer.
    Rugo HS, Crossno CL, Gesthalter YB, Kelley K, Moore HB, Rimawi MF, Westbrook KE, Buys SS| | PubMed
  13. Impact of a Dedicated Pleural Clinic on Indwelling Pleural Catheter Related Outcomes: A Retrospective Single Center Experience.
    Malcolm KB, Seeley EJ, Gesthalter YB| | PubMed
  14. Use of tunneled pleural catheters in chronic empyema: Two case reports and brief review of the literature.
    Krumm IR, Gesthalter YB| | PubMed
  15. Tracheal Reconstruction Using Endotracheal Stent and Pectoralis Major Muscle Flap.
    Ali B. Abbasi, Andre Alcon, Alap Patel, Yaron Gesthalter, William Hoffman, Johannes Kratz| | UCSF Research Profile
  16. Acquired Benign Tracheoesophageal Fistula: Novel Use of a Nasal Septal Occluder.
    Bawaadam HS, Russell M, Gesthalter YB| | PubMed
  17. Bleeding Risk With Combination Intrapleural Fibrinolytic and Enzyme Therapy in Pleural Infection: An International, Multicenter, Retrospective Cohort Study.
    Akulian J, Bedawi EO, Abbas H, Argento C, Arnold DT, Balwan A, Batra H, Uribe Becerra JP, Belanger A, Berger K, Burks AC, Chang J, Chrissian AA, DiBardino DM, Fuentes XF, Gesthalter YB, Gilbert CR, Glisinski K, Godfrey M, Gorden JA, Grosu H, Gupta M, Kheir F, Ma KC, Majid A, Maldonado F, Maskell NA, Mehta H, Mercer J, Mullon J, Nelson D, Nguyen E, Pickering EM, Puchalski J, Reddy C, Revelo AE, Roller L, Sachdeva A, Sanchez T, Sathyanarayan P, Semaan R, Senitko M, Shojaee S, Story R, Thiboutot J, Wahidi M, Wilshire CL, Yu D, Zouk A, Rahman NM, Yarmus L, Interventional Pulmonary Outcomes Group| | PubMed
  18. Ambulatory Management of a Recurrent Pneumothorax With an Indwelling Tunneled Pleural Catheter.
    Bawaadam HS, Boberg M, Gesthalter YB| | PubMed
  19. Erector Spinae Plane Block: A Novel Anesthetic Approach for Pleuroscopy.
    Sharp A, Mudda G, Braehler MR, Gesthalter YB| | PubMed
  20. Immunosuppression-Induced Pulmonary Alveolar Proteinosis Following Bilateral Lung Transplantation.
    J. Maheshwari, A. Perez, N. Kolaitis, D. Calabrese, A. Venado Estrada, J. Golden, R.J. Shah, L. Leard, M. Kleinhenz, K. Jones, A. Urisman, J. Kukreja, B. Trinh, Y. Gesthalter, J. Singer, S. Hays| | UCSF Research Profile
  21. Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology.
    Thompson JA, Schneider BJ, Brahmer J, Achufusi A, Armand P, Berkenstock MK, Bhatia S, Budde LE, Chokshi S, Davies M, Elshoury A, Gesthalter Y, Hegde A, Jain M, Kaffenberger BH, Lechner MG, Li T, Marr A, McGettigan S, McPherson J, Medina T, Mohindra NA, Olszanski AJ, Oluwole O, Patel SP, Patil P, Reddy S, Ryder M, Santomasso B, Shofer S, Sosman JA, Wang Y, Zaha VG, Lyons M, Dwyer M, Hang L| | PubMed
  22. Treatment of Advanced-Stage Non-Small Cell Lung Cancer.
    Gesthalter Y, Smyth R, Sullivan D| | PubMed
  23. Treatment of Early-Stage Non-Small Cell Lung Cancer.
    Gesthalter Y, Smyth R, Sullivan D| | PubMed
  24. Treatment of Small Cell Lung Cancer.
    Gesthalter Y, Smyth R| | PubMed
  25. Keep it Clean: Novel Use of Sterile Disposable Flexible Bronchoscopes for Pleuroscopy.
    Hamilton BCS, Gesthalter YB| | PubMed
  26. Lung Cancer Screening.
    Gesthalter YB, Seeley EJ| | PubMed
  27. A retrospective observational study of benign anthracotic lymphadenitis and its association with PET avid lymph nodes in patients undergoing cancer evaluation.
    Ivanick NM, Shrestha P, Podolsky MJ, Walavalkar V, Lucas CH, Gesthalter YB, Seeley EJ| | PubMed
  28. Smoking Cessation and Cancer.
    Gesthalter Y, Kathuria H, Moazed F, Tobacco Action Committee of the American Thoracic Society| | PubMed
  29. Decreasing 30-day Readmissions for Pleural Effusions after Lung Transplant.
    J.T. Teraoka, K.H. Nguyen, D. Hart, S. Peace, L. Leard, G. Iyer, D. Gordon, B. Zuckerman, J. Pascual, J. Ponzo, A. Perez, N. Budanova, Y. Gesthalter, B. Trinh, J. Kukreja, S. Hays, A. Venado| | UCSF Research Profile
  30. Key Highlights From the American Association for Bronchology and Interventional Pulmonology Evidence-Informed Guidelines and Expert Panel Report for the Management of Indwelling Pleural Catheters.
    Miller CRJ, Chrissian AA, Lee YCG, Rahman NM, Wahidi MM, Tremblay A, Hsia DW, Almeida FA, Shojaee S, Mudambi L, Belanger AR, Bedi H, Gesthalter YB, Gaynor M, MacKenney KL, Lewis SZ, Casal RF| | PubMed
  31. AABIP Evidence-informed Guidelines and Expert Panel Report for the Management of Indwelling Pleural Catheters.
    Miller RJ, Chrissian AA, Lee YCG, Rahman NM, Wahidi MM, Tremblay A, Hsia DW, Almeida FA, Shojaee S, Mudambi L, Belanger AR, Bedi H, Gesthalter YB, Gaynor M, MacKenney KL, Lewis SZ, Casal RF| | PubMed
  32. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.
    Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG| | PubMed
  33. Abstract 3377: NSCLC subtype-associated molecular and cellular alterations in the normal-appearing bronchial epithelium.
    Xingyi Shi, Jiarui Zhang, Steven Callori, Joshua Campbell, Denise Fine, Yaron Gesthalter, Gang Liu, Xiaohui Xiao, Avrum Spira, Marc Lenburg, Jennifer Beane| | UCSF Research Profile
  34. Flexible Bronchoscopic Deployment of a Silicone Bronchial Stent.
    Gesthalter YB, Seeley EJ| | PubMed
  35. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution.
    Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, Campbell JD, Beane J| | PubMed
  36. Indwelling Tunneled Pleural Catheters.
    Kheir F, Akulian J, Gesthalter YB| | PubMed
  37. Cryoprobe retrieval of an airway foreign body: A case report and literature review.
    David AP, Xu MJ, Rosbe KW, Meyer AK, Gesthalter YB, Chan DK| | PubMed
  38. Pulmonary Sclerosing Pneumocytoma.
    Rivera E, Gesthalter Y, VanderLaan P, Parikh MS| | PubMed
  39. Treatment of persistent bronchopleural fistula with a manually modified endobronchial stent: a case-report and brief literature review.
    de Lima A, Holden V, Gesthalter Y, Kent MS, Parikh M, Majid A, Chee A| | PubMed
  40. Bronchoscopic Management of Endobronchial Tumor in Patient With Hemoptysis and Acute Myocardial Infarction.
    Perez C, Kheir F, Barry M, Gesthalther Y, Majid A| | PubMed
  41. Impact of acute exposure to cigarette smoke on airway gene expression.
    Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME| | PubMed
  42. Sarcoidosis With Pleural Effusion as the Presenting Symptom.
    Rivera E, Gesthalter Y, Vardelaan P, Chee A, Majid A| | PubMed
  43. Evaluations of Implementation at Early-Adopting Lung Cancer Screening Programs: Lessons Learned.
    Gesthalter YB, Koppelman E, Bolton R, Slatore CG, Yoon SH, Cain HC, Tanner NT, Au DH, Clark JA, Wiener RS| | PubMed
  44. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.
    Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E, Cancer Prevention Network| | PubMed
  45. A Call to Formalize Training in Tobacco Dependence Treatment for Pulmonologists.
    Gesthalter YB, Wiener RS, Kathuria H| | PubMed
  46. Translating the transcriptome into tools for the early detection and prevention of lung cancer.
    Gesthalter YB, Vick J, Steiling K, Spira A| | PubMed
  47. Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention.
    Kathuria H, Gesthalter Y, Spira A, Brody JS, Steiling K| | PubMed