University of California San Francisco

Monika Sarkar MD MAS
Monika
Sarkar
MD, MAS

Associate Professor 
Department of Medicine
Division of Gastroenterology and Hepatology

Address

513 Parnassus Avenue, MSB, #357F
San Francisco, CA 94143
United States

Phone: 415-502-2656
Fax: 415-476-0659

    Biography

    My clinical focus is on women with liver disease, including pregnancy-related liver conditions and reproductive health. My research program is focused on the role of sex hormones in modulating liver disease in women. I have a specific research interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome given their high risk for developing Non Alcoholic Fatty Liver Disease (NAFLD) and early onset liver scarring. Within the transplant setting my focus is reproductive health, including pregnancy and contraceptive management in transplant recipients.

    Education

    Institution Degree Dept or School End Date
    UCSF Transplant Hepatology Fellowship 2013
    UCSF Gastroenterology Fellowship 2012
    UCSF M.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research) 2012
    University of Pennsylvania Internal Medicine Residency 2009
    UCSF M.D. School of Medicine 2006
    Vassar College BA 2002

    Board Certifications

    American Board of Internal Medicine
    American Board of Internal Medicine - Gastroenterology
    American Board of Internal Medicine - Transplant Hepatology

    Awards & Honors

    Award Conferred By Date
    R03 NIDDK 2022/2024
    K23 NIDDK 2017/2023
    K Scholars Team Science Award UCSF 2017/2018
    UCSF Hellman Research Award UCSF 2016/2018
    RAP Pilot Award for Junior Investigators UCSF 2016/2017
    Liver Center Flex Funds UCSF 2015/2016
    Liver Center Pilot/Feasibility Research Award UCSF Liver Center 2014/2015
    Sheila Sherlock Career Development Research Award AASLD 2013/2015
    Advanced Hepatology Fellowship Award AASLD 2012/2013

    Clinical Expertise

    Alcoholic Liver Disease
    Autoimmune Hepatitis
    Cirrhosis
    Drug-Induced Hepatitis
    Fulminant Hepatic Failure
    Hemochromatosis
    Hepatitis B
    Hepatitis C
    Hepatocellular Carcinoma (Liver Cancer)
    Liver Transplantation
    Living Donor Liver Transplantation
    Nonalcoholic Fatty Liver Disease
    Polycystic Liver Disease
    Primary Biliary Cirrhosis
    Primary Sclerosing Cholangitis

    Clinical Trials

    1. Related Conditions: Nonalcoholic Fatty Liver Disease, Polycystic Ovary Syndrome, Liver Disease| Start Date: | End Date:
    2. Related Conditions: Nonalcoholic Steatohepatitis, Steatohepatitis, Liver Disease, Nonalcoholic Fatty Liver Disease| Start Date: | End Date:

    Program Affiliations

    UCSF Liver Center

    Grants and Funding

    • Influence of Androgens on Tissue-Specific Lipid Metabolites and Liver Injury in Young Women with NAFLD | NIDDK | 2022-03-15 - 2024-03-15 | Role: Principle Investigator
    • Androgens and Nonalcoholic Steatohepatitis: The Role of Male Sex Hormones in Women with NASH | NIH | 2017-07-10 - 2023-06-30 | Role: Principal Investigator

    Research Narrative

    My research program is focused on the role of sex hormones on liver injury in women, including the effects of reproductive aging, pregnancy, and androgens. I have a specific interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome as these women are at high risk for developing Non Alcoholic Fatty Liver Disease and early onset liver scarring. Within the transplant setting I also study sex differences in waitlist and post transplant outcomes.

    Research Interests

    Women with chronic liver disease

    Non invasive measures of liver fibrosis

    Gender differences in liver transplant outcomes

     

    Publications

    MOST RECENT PUBLICATIONS FROM A TOTAL OF 88
    1. Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women.
      Rubin JB, Hameed B, Gottfried M, Lee WM, Sarkar M, Acute Liver Failure Study Group| | PubMed
    2. Moderate Alcohol Use Is Not Associated With Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women: A Prospective Cohort Study.
      Kelly EM, Dodge JL, Bacchetti P, Sarkar M, French AL, Tien PC, Glesby MJ, Golub ET, Augenbraun M, Plankey M, Peters MG| | PubMed
    3. Perinatal programming of adolescent nonalcoholic fatty liver disease: A case for gender inequality?
      Sarkar M, Baffy G| | PubMed
    4. Reproductive Aging and Hepatic Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women.
      Sarkar M, Dodge JL, Greenblatt RM, Kuniholm MH, DeHovitz J, Plankey M, Kovacs A, French AL, Seaberg EC, Ofotokun I, Fischl M, Overton E, Kelly E, Bacchetti P, Peters MG, Women’s Interagency HIV Study| | PubMed
    5. Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife.
      Sarkar M, Wellons M, Cedars MI, VanWagner L, Gunderson EP, Ajmera V, Torchen L, Siscovick D, Carr JJ, Terry JG, Rinella M, Lewis CE, Terrault N| | PubMed
    6. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition.
      Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM| | PubMed
    7. Sex differences in the association of HIV infection with hepatic steatosis.
      Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC| | PubMed
    8. Increased hepatocellular carcinoma recurrence in women compared to men with high alpha fetoprotein at liver transplant.
      Sarkar M, Dodge JL, Roberts JP, Terrault N, Yao F, Mehta N| | PubMed
    9. Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women.
      Kuniholm MH, O'Brien TR, Prokunina-Olsson L, Augenbraun M, Plankey M, Karim R, Sarkar M, French AL, Pierce C, Strickler HD, Anastos K| | PubMed
    10. Marijuana Use Is Not Associated With Progression to Advanced Liver Fibrosis in HIV/Hepatitis C Virus-coinfected Women.
      Kelly EM, Dodge JL, Sarkar M, French AL, Tien PC, Glesby MJ, Golub ET, Augenbraun M, Plankey M, Peters MG| | PubMed