University of California San Francisco

Monika Sarkar MD MAS
Monika
Sarkar
MD, MAS

Associate Professor 
Department of Medicine
Division of Gastroenterology and Hepatology

Address

513 Parnassus Avenue, MSB, #357F
San Francisco, CA 94143
United States

Phone: 415-502-2656
Fax: 415-476-0659

    Biography

    My clinical focus is on women with liver disease, including pregnancy-related liver conditions and reproductive health. My research program is focused on the role of sex hormones in modulating liver disease in women. I have a specific research interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome given their high risk for developing Non Alcoholic Fatty Liver Disease (NAFLD) and early onset liver scarring. Within the transplant setting my focus is reproductive health, including pregnancy and contraceptive management in transplant recipients.

    Education

    Institution Degree Dept or School End Date
    UCSF Transplant Hepatology Fellowship 2013
    UCSF Gastroenterology Fellowship 2012
    UCSF M.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research) 2012
    University of Pennsylvania Internal Medicine Residency 2009
    UCSF M.D. School of Medicine 2006
    Vassar College BA 2002

    Board Certifications

    American Board of Internal Medicine
    American Board of Internal Medicine - Gastroenterology
    American Board of Internal Medicine - Transplant Hepatology

    Awards & Honors

    Award Conferred By Date
    R03 NIDDK 2022/2024
    K23 NIDDK 2017/2023
    K Scholars Team Science Award UCSF 2017/2018
    UCSF Hellman Research Award UCSF 2016/2018
    RAP Pilot Award for Junior Investigators UCSF 2016/2017
    Liver Center Flex Funds UCSF 2015/2016
    Liver Center Pilot/Feasibility Research Award UCSF Liver Center 2014/2015
    Sheila Sherlock Career Development Research Award AASLD 2013/2015
    Advanced Hepatology Fellowship Award AASLD 2012/2013

    Clinical Expertise

    Alcoholic Liver Disease
    Autoimmune Hepatitis
    Cirrhosis
    Drug-Induced Hepatitis
    Fulminant Hepatic Failure
    Hemochromatosis
    Hepatitis B
    Hepatitis C
    Hepatocellular Carcinoma (Liver Cancer)
    Liver Transplantation
    Living Donor Liver Transplantation
    Nonalcoholic Fatty Liver Disease
    Polycystic Liver Disease
    Primary Biliary Cirrhosis
    Primary Sclerosing Cholangitis

    Clinical Trials

    1. Related Conditions: Nonalcoholic Fatty Liver Disease, Polycystic Ovary Syndrome, Liver Disease| Start Date: | End Date:
    2. Related Conditions: Nonalcoholic Steatohepatitis, Steatohepatitis, Liver Disease, Nonalcoholic Fatty Liver Disease| Start Date: | End Date:

    Program Affiliations

    UCSF Liver Center

    Grants and Funding

    • Influence of Androgens on Tissue-Specific Lipid Metabolites and Liver Injury in Young Women with NAFLD | NIDDK | 2022-03-15 - 2024-03-15 | Role: Principle Investigator
    • Androgens and Nonalcoholic Steatohepatitis: The Role of Male Sex Hormones in Women with NASH | NIH | 2017-07-10 - 2023-06-30 | Role: Principal Investigator

    Research Narrative

    My research program is focused on the role of sex hormones on liver injury in women, including the effects of reproductive aging, pregnancy, and androgens. I have a specific interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome as these women are at high risk for developing Non Alcoholic Fatty Liver Disease and early onset liver scarring. Within the transplant setting I also study sex differences in waitlist and post transplant outcomes.

    Research Interests

    Women with chronic liver disease

    Non invasive measures of liver fibrosis

    Gender differences in liver transplant outcomes

     

    Publications

    MOST RECENT PUBLICATIONS FROM A TOTAL OF 88
    1. Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.
      Sarkar M, Grab J, Dodge JL, Gunderson EP, Rubin J, Irani RA, Cedars M, Terrault N| | PubMed
    2. Pregnancy in Liver Transplantation.
      Sarkar M, Sawinski D, Coscia L, American Society of Transplantation, Women’s Health Community of Practice| | PubMed
    3. 1004 PREGNANCIES WITH CIRRHOSIS ARE RISING AND ASSOCIATED WITH ADVERSE MATERNAL AND FETAL OUTCOMES.
      Annsa C. Huang, Joshua Grab, Jennifer A. Flemming, Jennifer L. Dodge, Monika Sarkar| | UCSF Research Profile
    4. Shorter Height Is Associated With Lower Probability of Liver Transplantation in Patients With Hepatocellular Carcinoma.
      Lee E, Sarkar M, Dodge J, Kohi M, Mehta N| | PubMed
    5. Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.
      Sarkar M, Yates K, Suzuki A, Lavine J, Gill R, Ziegler T, Terrault N, Dhindsa S| | PubMed
    6. NAFLD in women: Unique pathways, biomarkers and therapeutic opportunities.
      Yuan L, Kardashian A, Sarkar M| | PubMed
    7. Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis.
      Sarkar M, Terrault N, Chan W, Cedars MI, Huddleston HG, Duwaerts CC, Balitzer D, Gill RM| | PubMed
    8. Deficiencies in Reproductive Health Counseling in Liver Transplant Patients [2H].
      Julia Ritchie, Dominika Seidman, Yanin Srisengfa, Vanessa L. Jacoby, Emily Perito, Monika Sarkar| | UCSF Research Profile
    9. Sa1623 – Low Testosterone is Associated with Nash and Fibrosis Severity in Men with Nafld.
      Monika Sarkar, Katherine P. Yates, Ayako Suzuki, Joel E. Lavine, Ryan M. Gill, Norah Terrault, Sandeep Dhindsa| | UCSF Research Profile
    10. Sex Hormone-Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife.
      Sarkar M, VanWagner LB, Terry JG, Carr JJ, Rinella M, Schreiner PJ, Lewis CE, Terrault N, Coronary Artery Risk Development in Young Adults (CARDIA) Cohort| | PubMed