Biography
Dr. Michael Alvarado is a cancer surgeon who cares for patients with breast cancer and melanoma at the UCSF Helen Diller Family Comprehensive Cancer Center at Mount Zion.
In his research, Alvarado conducts trials of radiation therapy for breast cancer. He also studies blood-based and molecular markers with the goal of improving breast cancer screening.
Alvarado earned a master's degree in chemistry at the University of Arizona and a medical degree at Dartmouth College’s Geisel School of Medicine. After completing a residency at Dartmouth-Hitchcock Medical Center, he completed a surgical oncology fellowship at the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida.
In his research, Alvarado conducts trials of radiation therapy for breast cancer. He also studies blood-based and molecular markers with the goal of improving breast cancer screening.
Alvarado earned a master's degree in chemistry at the University of Arizona and a medical degree at Dartmouth College’s Geisel School of Medicine. After completing a residency at Dartmouth-Hitchcock Medical Center, he completed a surgical oncology fellowship at the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Darmouth | M.D. | School of Medicine | 1998 |
Board Certifications
- 2005, American Board of Surgery
Clinical Expertise
Breast Reconstruction
DCIS (Ductal Carcinoma in situ)
Inflammatory Breast Cancer
Invasive Breast Cancer
LCIS (Lobular Carcinoma in situ)
Lumpectomy/Partial Mastectomy
Lymphadenectomy
Mastectomy
Melanoma
Merkel Cell Carcinoma
Recurrent Breast Cancer
Sentinel Lymph Node Biopsy
Wire Localization Surgery
Clinical Trials
- Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery (NCT01570998)Related Conditions: Breast Cancer| Start Date: | End Date:
- SentiMag® Intraoperative Comparison in Breast Cancer (NCT02336737)Related Conditions: Breast Cancer| Start Date: | End Date:
Program Affiliations
- UCSF Helen Diller Family Comprehensive Cancer Center
- UCSF Melanoma Center
- Carol Franc Buck Breast Care Center
Research Interests
Investigation of blood-based and molecular markers to improve breast cancer screening
Sentinel Lymph Node Biopsy
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 87
- Predictors of Early Versus Late Recurrence in Invasive Lobular Carcinoma of the Breast: Impact of Local and Systemic Therapy.| | View in PubMed
- Changes in Surgical Management of the Axilla Over 11 Years - Report on More Than 1500 Breast Cancer Patients Treated with Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial.| | View in PubMed
- Breast Conservation Surgery and Mastectomy Have Similar Locoregional Recurrence After Neoadjuvant Chemotherapy: Results From 1462 Patients on the Prospective, Randomized I-SPY2 Trial.| | View in PubMed
- Expanding Candidacy for Nipple-sparing Mastectomy in Women with Large or Ptotic Breasts: Staged Reconstruction Outcomes.| | View in PubMed
- In Regard to Hammer et al.| | View in PubMed
- In Reply to Ward et al.| | View in PubMed
- The TARGIT-A Randomized Trial: TARGIT-IORT Versus Whole Breast Radiation Therapy: Long-Term Local Control and Survival.| | View in PubMed
- Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial.| | View in PubMed
- Should Sentinel Lymph Node Biopsy Status Guide Adjuvant Radiation Therapy in Patients With Merkel Cell Carcinoma?| | View in PubMed
- Positive margins after mastectomy in patients with invasive lobular carcinoma of the breast: Incidence and management strategies.| | View in PubMed
- Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection.| | View in PubMed
- New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer.| | View in PubMed
- Accuracy of breast MRI in evaluating nodal status after neoadjuvant therapy in invasive lobular carcinoma.| | View in PubMed
- Intraoperative radiotherapy for breast cancer: powerful evidence to change practice.| | View in PubMed
- In Regard to Polgar et al.| | View in PubMed
- Accuracy of sentinel lymph node biopsy in invasive lobular carcinoma of the breast: Factors associated with false negatives.| | View in PubMed
- Correction to: SentimagIC: A Non-inferiority Trial Comparing Superparamagnetic Iron Oxide Versus Technetium-99m and Blue Dye in the Detection of Axillary Sentinel Nodes in Patients with Early-Stage Breast Cancer.| | View in PubMed
- Oncological Outcomes of Total Skin-Sparing Mastectomy for Invasive Lobular Carcinoma of the Breast: A 20-Year Institutional Experience.| | View in PubMed
- Layilin augments integrin activation to promote antitumor immunity.| | View in PubMed
- Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.| | View in PubMed
- Evaluating the impact of axillary dissection on recurrence-free survival by extent of nodal disease in invasive lobular carcinoma of the breast.| | View in PubMed
- Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer.| | View in PubMed
- Breast conservation therapy versus mastectomy in the surgical management of invasive lobular carcinoma measuring 4 cm or greater.| | View in PubMed
- Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.| | View in PubMed
- Mitotic score and pleomorphic histology in invasive lobular carcinoma of the breast: impact on disease-free survival.| | View in PubMed
- Success rates of re-excision after positive margins for invasive lobular carcinoma of the breast.| | View in PubMed
- SentimagIC: A Non-inferiority Trial Comparing Superparamagnetic Iron Oxide Versus Technetium-99m and Blue Dye in the Detection of Axillary Sentinel Nodes in Patients with Early-Stage Breast Cancer.| | View in PubMed
- Feasibility of Magnetic Seeds for Preoperative Localization of Axillary Lymph Nodes in Breast Cancer Treatment.| | View in PubMed
- Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer.| | View in PubMed
- Erratum: Author Correction: Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.| | View in PubMed
- Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.| | View in PubMed
- Breast Conservation and Negative Margins in Invasive Lobular Carcinoma: The Impact of Oncoplastic Surgery and Shave Margins in 358 Patients.| | View in PubMed
- A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.| | View in PubMed
- Initial Clinical Experience With an Inducible Magnetic Seed System for Preoperative Breast Lesion Localization.| | View in PubMed
- Complications After Total Skin-Sparing Mastectomy and Expander-Implant Reconstruction: Effects of Radiation Therapy on the Stages of Reconstruction.| | View in PubMed
- Best practices for multidisciplinary integration of a DCIS genomic assay into clinical practice.| | View in PubMed
- Indications for Postmastectomy Radiation After Neoadjuvant Chemotherapy in ypN0 and ypN1-3 Axillary Node-Positive Women.| | View in PubMed
- Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.| | View in PubMed
- Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.| | View in PubMed
- Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013.| | View in PubMed
- Less Is More: The Evolving Surgical Approach to Breast Cancer.| | View in PubMed
- The Impact of Radiation Therapy, Lymph Node Dissection, and Hormonal Therapy on Outcomes of Tissue Expander-Implant Exchange in Prosthetic Breast Reconstruction.| | View in PubMed
- Tissue Expander Reconstruction After Total Skin-Sparing Mastectomy: Defining the Effects of Coverage Technique on Nipple/Areola Preservation.| | View in PubMed
- Sentinel Lymph Node Mapping in Post-Mastectomy Chest Wall Recurrences: Influence on Radiation Treatment Fields and Outcome.| | View in PubMed
- A Prospective Comparison of the 21-Gene Recurrence Score and the PAM50-Based Prosigna in Estrogen Receptor-Positive Early-Stage Breast Cancer.| | View in PubMed
- Negative Genetic Testing Does Not Deter Contralateral Prophylactic Mastectomy in Younger Patients with Greater Family Histories of Breast Cancer.| | View in PubMed
- Expanding the Indications for Total Skin-Sparing Mastectomy: Is It Safe for Patients with Locally Advanced Disease?| | View in PubMed
- In Regard to Hepel and Wazer.| | View in PubMed
- In Regard to Hepel and Wazer.| | View in PubMed
- Tumor Involvement of the Nipple in Total Skin-Sparing Mastectomy: Strategies for Management.| | View in PubMed
- The impact of genomic testing on the recommendation for radiation therapy in patients with ductal carcinoma in situ: A prospective clinical utility assessment of the 12-gene DCIS score™ result.| | View in PubMed
- Rates of Reconstruction Failure in Patients Undergoing Immediate Reconstruction With Tissue Expanders and/or Implants and Postmastectomy Radiation Therapy.| | View in PubMed
- Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer.| | View in PubMed
- The impact of breast mass on outcomes of total skin-sparing mastectomy and immediate tissue expander-based breast reconstruction.| | View in PubMed
- Immediate implant-based breast reconstruction following total skin-sparing mastectomy: defining the risk of preoperative and postoperative radiation therapy for surgical outcomes.| | View in PubMed
- Haste makes waste, but lack of urgency is opportunity lost.| | View in PubMed
- Total skin-sparing mastectomy and immediate breast reconstruction: an evolution of technique and assessment of outcomes.| | View in PubMed
- Immediate implant-based breast reconstruction following total skin-sparing mastectomy in women with a history of augmentation mammaplasty: assessing the safety profile.| | View in PubMed
- Local recurrence rates are low in high-risk neoadjuvant breast cancer in the I-SPY 1 Trial (CALGB 150007/150012; ACRIN 6657).| | View in PubMed
- The current clinical value of the DCIS Score.| | View in PubMed
- Setting a research agenda for ductal carcinoma in situ that meets the current need for change.| | View in PubMed
- Abstract 124: outcomes of total skin-sparing mastectomy and reconstruction in 924 breasts over 11 years.| | View in PubMed
- Memory regulatory T cells reside in human skin.| | View in PubMed
- Patient preferences regarding intraoperative versus external beam radiotherapy following breast-conserving surgery.| | View in PubMed
- Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial.| | View in PubMed
- Total skin-sparing mastectomy in BRCA mutation carriers.| | View in PubMed
- Cost-effectiveness analysis of intraoperative radiation therapy for early-stage breast cancer.| | View in PubMed
- Author's reply to Lamy.| | View in PubMed
- Clinical validity/utility, change in practice patterns, and economic implications of risk stratifiers to predict outcomes for early-stage breast cancer: a systematic review.| | View in PubMed
- Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy.| | View in PubMed
- The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study.| | View in PubMed
- Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts.| | View in PubMed
- Overdiagnosis and overtreatment of breast cancer.| | View in PubMed
- The impact of preoperative magnetic resonance imaging on surgical treatment and outcomes for ductal carcinoma in situ.| | View in PubMed
- Impact of chemotherapy on postoperative complications after mastectomy and immediate breast reconstruction.| | View in PubMed
- Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.| | View in PubMed
- Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?| | View in PubMed
- Gene expression profiling of colorectal mucinous adenocarcinomas.| | View in PubMed
- Bacteriologic features of surgical site infections following breast surgery.| | View in PubMed
- Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancer.| | View in PubMed
- Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patients.| | View in PubMed
- Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer?| | View in PubMed
- Surgery for palliation and treatment of advanced breast cancer.| | View in PubMed
- The value of sentinel lymph node biopsy in the management of head and neck melanoma.| | View in PubMed
- Down-regulation of pro-apoptotic genes is an early event in the progression of malignant melanoma.| | View in PubMed
- Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors.| | View in PubMed
- The potential role of gene expression in the management of primary and metastatic colorectal cancer.| | View in PubMed