Biography
My research addresses clinical questions by studying human subjects or patients. I collaborate with other faculty in the department on my research and provide expertise in the following areas: data analysis and statistics; mathematical modeling; data acquisition programming; human studies; respiratory physiology.
My research involvement has included multiple different projects:
• Accuracy of pulse oximetry, including determination of methemoglobin, carboxyhemoglobin, and the accuracy of cerebral oximetry.
• Organ transplantation and efforts to improve the quality of cadaveric organs.
• Acute normovolemic hemodilution to study the tolerance of acute anemia, as a way to examine red cell transfusion thresholds. Additionally, we have used this model to study other issues in transfusion, including TRALI.
• The utility of somatosensory and motor evoked potential, which are used in major spine surgery to assess the integrity of spinal cord function.
• The physiology of breathholding and drug-induced apnea.
• High altitude physiology
• Clinical effects of neuromuscular blockade
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
American Board of Anesthesiology
Clinical Expertise
Kidney Transplantation
Liver Transplantation
Pancreas Transplantation
Clinical Trials
- Accuracy of BabySat V3 With Profound Hypoxia and Motion (NCT05581394)Related Conditions: Hypoxia| Start Date: | End Date:
- Related Conditions: Hypoxia| Start Date: | End Date:
- Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude (NCT02233582)Related Conditions: High Altitude| Start Date: | End Date:
- Related Conditions: Muscle Relaxation, Sex| Start Date: | End Date:
Program Affiliations
- Department of Anesthesia and Perioperative Care
- Department of Surgery, Division of Transplantation
In the News
Research Interests
Hypoxic ventilatory drive at altitude
Apnea with remifentanil and propofol
Transfusion Related Acute Lung Injury
Neuromonitoring in Spine Anesthesia
Pulse oximeter accuracy
Physiology of acute anemia
Predictors of kidney and liver donor organ function
View Research Profile at UCSF Clinical & Translational Science Institute
Publications
- Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis.| | PubMed
- Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion.| | PubMed
- Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects.| | PubMed
- Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance.| | PubMed
- Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations.| | PubMed
- Incidence and Management of Umbilical Artery Flow Abnormalities during Open Fetal Surgery.| | PubMed
- Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance.| | PubMed
- Evaluating Pulmonary Function: An Assessment of PaO2/FIO2.| | PubMed
- Tissue Oximetry and Clinical Outcomes.| | PubMed
- The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications.| | PubMed