Biography
Dr. Jablons received his medical degree from Albany Medical College. During medical school, he was awarded an NCI preceptorship allowing him to train under Steven Rosenberg, a world-renowned surgeon and tumor immunologist. This experience kindled Dr. Jablons lifelong interest in translational and precision medicine. Dr. Jablons then completed his general surgery residency at Tufts-New England Medical Center and his thoracic surgery residency at what is now New York Presbyterian-Weill Cornell Medical Center. His mentors included Robert Ginsburg at Memorial Sloan-Kettering and David Sugarbaker at Brigham & Women's Hospital, both world-renown thoracic surgical oncologists. Dr. Jablons also served as a Navy commander while Chief of Thoracic Surgery at the Oakland Naval Hospital. In 1997, he was named Chief of General Thoracic Surgery at UCSF.
Dr. Jablons is a highly accomplished thoracic surgeon, widely sought out by patients in the Bay Area and world-wide. One patient, Bonnie J. Addario, after recovering from an arduous lung cancer surgery, started a foundation bearing her name she co-founded with Dr. Jablons. Today, the Addario Foundation is one of the leading underwriters of lung cancer research. Dr. Jablons has also been a dedicated teacher and outstanding mentor for both for clinical fellows and surgical residents, the latter including Dan Raz and Johannes Kratz, protégés with an enviable and prolific record of publications who helped spearhead development of predictive and prognostic tools for lung cancer treatment in the lab.
Dr. Jablons has been a trailblazer in educational outreach, co-founding the UCSF Thoracic Oncology Conference, an annual symposium that provided expert training for thousands of community surgeons for over a decade. He also was instrumental in establishing the China Clinical Trials Consortium to find more effective treatments for lung cancer, and to ameliorate the epidemic of lung cancer in China. In 2009, he led the effort to bring World Conference on Lung Cancer to San Francisco, the preeminent event in the field, in which he served as co-Chair.
He is a member of numerous professional organizations including the Society of Thoracic Surgeons, the American College of Chest Physicians, the American Association for Cancer Research and the International Association for the Study of Lung Cancer (IASLC). Highly respected by his peers, Dr. Jablons was named to the list of U.S. News "America's Top Doctors," a distinction reserved for the top 1% of physicians in the nation for a given specialty. Dr. Jablons was recently inducted into the American Surgical Society, the nation's most prestigious.
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Surgical Resident Teaching Award | University of California, San Francisco | 2001 |
Surgical Resident Teaching Award | University of California, San Francisco | 1999 |
Education
Yale University, B.A., American Literature, 1979
Albany Medical College of Union University, M.D., 1984
Oak Knoll Naval Hospital, Oakland, CA, General Surgery, 1984-85
Tufts University/New England Medical Center, General Surgery, 1985-86, 89-91
Weill Cornell University Medical Center, Cardiothoracic Surgery, 1991-93
NCI/NIH, Surgery Branch, Surgical Oncology, 1986-89
Brigham & Women's Hospital, Lung Transplantation, 1992
New York Hospital/Memorial Sloan Kettering Cancer Center, Thoracic Surgery, 1992-93
Board Certifications
American Board of Surgery
American Board of Thoracic Surgery
Clinical Expertise
Bronchioloalveolar Carcinoma (BAC)
Carcinoid Tumors
Chest Wall Tumors
Esophageal Cancer
Esophagectomy
Lung Metastases
Lung Transplantation
Lung Volume Reduction Surgery
Malignant Mesothelioma
Mediastinal Masses
Robotic Thoracic Surgery
Minimally Invasive Thoracic Surgery
Non-Small Cell Lung Cancer
Sarcomas
Small Cell Lung Cancer
Thymoma & Thymic Carcinoma
Tracheal Tumors
Video-Assisted Thoracoscopic Surgery (VATS)
Program Affiliations
Thoracic Oncology Program
Member, UCSF Helen Diller Family Comprehensive Cancer Center
In the News
Grants and Funding
- Inflammation and Lung Carcinogenesis | NIH | 2008-05-01 - 2014-03-31 | Role: Principal Investigator
- The Wnt Pathway in Malignant Mesothelioma | NIH | 2005-03-01 - 2010-02-28 | Role: Principal Investigator
Research Narrative
The Thoracic Oncology Lab focuses on drug target discovery, commercialization of novel therapeutics and development of genomic assays based on predictive and prognostic biomarkers.
Research Interests
Early Detection and Screening
Prognostic molecular multi-gene assays in Early-Stage NSCLC
Discovery of novel therapeutic targets in in thoracic malignancies
Investigation of signal transduction pathways including Wnt, Hedgehog, and Hippo in lung cancer and mesothelioma
Isolation of lung cancer stems cells
Inflammation in lung carcinogenesis
Study of "systems genetics" in thoracic malignancies
Next generation sequencing
Clinical outcomes research
Lung cancer epigenetics and emerging biomarkers
Research Pathways
Publications
- Novel dual action PARP and microtubule polymerization inhibitor AMXI-5001 powerfully inhibits growth of esophageal carcinoma both alone and in combination with radiotherapy.| | View in PubMed
- Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer.| | View in PubMed
- Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas.| | View in PubMed
- SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.| | View in PubMed
- MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway.| | View in PubMed
- Genetic and immunologic features of recurrent stage I lung adenocarcinoma.| | View in PubMed
- Perioperative Lung Resection Outcomes After Implementation of a Multidisciplinary, Evidence-based Thoracic ERAS Program.| | View in PubMed
- The effect of cullin 4A on lung cancer cell chemosensitivity to paclitaxel through p33ING1b regulation.| | View in PubMed
- Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay.| | View in PubMed
- Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early-Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit From Adjuvant Chemotherapy.| | View in PubMed
- SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.| | View in PubMed
- Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.| | View in PubMed
- Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity.| | View in PubMed
- Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models.| | View in PubMed
- A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells.| | View in PubMed
- Development of novel monoclonal antibodies and immunoassays for sensitive and specific detection of SULF1 endosulfatase.| | View in PubMed
- Ponatinib is a potential therapeutic approach for malignant pleural mesothelioma.| | View in PubMed
- Evaluation of a National Comprehensive Cancer Network Guidelines-Based Decision Support Tool in Patients With Non-Small Cell Lung Cancer: A Nonrandomized Clinical Trial.| | View in PubMed
- Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.| | View in PubMed
- AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers.| | View in PubMed
- The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).| | View in PubMed
- Surgery for pleural mesothelioma, when it is indicated and why: arguments against surgery for malignant pleural mesothelioma.| | View in PubMed
- Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells.| | View in PubMed
- Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma.| | View in PubMed
- Case report: recurrent metastatic breast cancer in internal mammary dissection bed discovered at the time of coronary bypass.| | View in PubMed
- Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC).| | View in PubMed
- The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.| | View in PubMed
- Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.| | View in PubMed
- Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model.| | View in PubMed
- Cul4A Modulates Invasion and Metastasis of Lung Cancer Through Regulation of ANXA10.| | View in PubMed
- Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging.| | View in PubMed
- Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development.| | View in PubMed
- The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer.| | View in PubMed
- Central Airway Obstruction Due to Tracheal Glomus Tumor.| | View in PubMed
- Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation.| | View in PubMed
- Scientific Advances and New Frontiers in Mesothelioma Therapeutics.| | View in PubMed
- Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.| | View in PubMed
- Transfer of multiple loci of donor's genes to induce recipient tolerance in organ transplantation.| | View in PubMed
- Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma.| | View in PubMed
- Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.| | View in PubMed
- Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog.| | View in PubMed
- Old Sonic Hedgehog, new tricks: a new paradigm in thoracic malignancies.| | View in PubMed
- YAP regulates PD-L1 expression in human NSCLC cells.| | View in PubMed
- Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma.| | View in PubMed
- Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer.| | View in PubMed
- Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden.| | View in PubMed
- Hippo pathway in lung development.| | View in PubMed
- Systematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues.| | View in PubMed
- Drug development against the hippo pathway in mesothelioma.| | View in PubMed
- Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer.| | View in PubMed
- DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.| | View in PubMed
- Targeting YAP in malignant pleural mesothelioma.| | View in PubMed
- Management of Lung Cancer Invading the Superior Sulcus.| | View in PubMed
- Mobile Genome Express (MGE): A comprehensive automatic genetic analyses pipeline with a mobile device.| | View in PubMed
- YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells.| | View in PubMed
- Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas.| | View in PubMed
- FAIM2, as a novel diagnostic maker and a potential therapeutic target for small-cell lung cancer and atypical carcinoid.| | View in PubMed
- Hybrid minimally invasive Ivor Lewis esophagectomy after neoadjuvant chemoradiation yields excellent long-term survival outcomes with minimal morbidity.| | View in PubMed
- Development of a robust DNA quality and quantity assessment qPCR assay for targeted next-generation sequencing library preparation.| | View in PubMed
- YAP promotes erlotinib resistance in human non-small cell lung cancer cells.| | View in PubMed
- Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far.| | View in PubMed
- Comprehensive evaluation and validation of targeted next-generation sequencing performance in two clinical laboratories.| | View in PubMed
- Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells.| | View in PubMed
- SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer.| | View in PubMed
- Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas.| | View in PubMed
- Lung Cancer Staging and Prognosis.| | View in PubMed
- Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells.| | View in PubMed
- Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.| | View in PubMed
- EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas.| | View in PubMed
- Operative and Perioperative Pulmonary Emboli.| | View in PubMed
- Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.| | View in PubMed
- PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.| | View in PubMed
- Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.| | View in PubMed
- NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer.| | View in PubMed
- Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.| | View in PubMed
- Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.| | View in PubMed
- Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma.| | View in PubMed
- The Latest in Surgical Management of Stage IIIA Non-Small Cell Lung Cancer: Video-Assisted Thoracic Surgery and Tumor Molecular Profiling.| | View in PubMed
- CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.| | View in PubMed
- Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer.| | View in PubMed
- Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.| | View in PubMed
- Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer.| | View in PubMed
- An alternative way to initiate Notch1 signaling in non-small cell lung cancer.| | View in PubMed
- Divergent management strategies for typical versus atypical carcinoid tumors of the thoracic cavity.| | View in PubMed
- The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma.| | View in PubMed
- Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.| | View in PubMed
- Lung tumourigenesis in a conditional Cul4A transgenic mouse model.| | View in PubMed
- Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas.| | View in PubMed
- A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.| | View in PubMed
- Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma.| | View in PubMed
- Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.| | View in PubMed
- VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer.| | View in PubMed
- Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.| | View in PubMed
- Desmoplastic fibroma of the spine causing severe mediastinal compression and brachial plexus encasement: report of 2 cases.| | View in PubMed
- Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma.| | View in PubMed
- Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.| | View in PubMed
- Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2.| | View in PubMed
- Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.| | View in PubMed
- Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.| | View in PubMed
- International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature.| | View in PubMed
- Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer.| | View in PubMed
- Targeting Gli transcription activation by small molecule suppresses tumor growth.| | View in PubMed
- Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.| | View in PubMed
- Gli as a novel therapeutic target in malignant pleural mesothelioma.| | View in PubMed
- Prognostic assay in small, node-negative non-small cell lung cancer--reply.| | View in PubMed
- SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma.| | View in PubMed
- Molecular prognostication of non-small cell lung cancer.| | View in PubMed
- Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.| | View in PubMed
- Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.| | View in PubMed
- SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study.| | View in PubMed
- The role of stem cells in airway repair: implications for the origins of lung cancer.| | View in PubMed
- A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors.| | View in PubMed
- Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.| | View in PubMed
- A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease.| | View in PubMed
- Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.| | View in PubMed
- The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma.| | View in PubMed
- One size does not fit all lung cancer patients.| | View in PubMed
- Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.| | View in PubMed
- A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.| | View in PubMed
- Implications of delayed initiation of radiotherapy: accelerated repopulation after induction chemotherapy for stage III non-small cell lung cancer.| | View in PubMed
- Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.| | View in PubMed
- Wnt and hedgehog gene pathway expression in serous ovarian cancer.| | View in PubMed
- The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance.| | View in PubMed
- Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.| | View in PubMed
- Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.| | View in PubMed
- Transgenic mice for cre-inducible overexpression of the Cul4A gene.| | View in PubMed
- Cul4A is an oncogene in malignant pleural mesothelioma.| | View in PubMed
- The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.| | View in PubMed
- Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells.| | View in PubMed
- Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest.| | View in PubMed
- Lung cancer therapeutics that target signaling pathways: an update.| | View in PubMed
- EMX2 is epigenetically silenced and suppresses growth in human lung cancer.| | View in PubMed
- Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.| | View in PubMed
- Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.| | View in PubMed
- Cancer stem cells in lung tumorigenesis.| | View in PubMed
- Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site.| | View in PubMed
- Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.| | View in PubMed
- A safe and reproducible anastomotic technique for minimally invasive Ivor Lewis oesophagectomy: the circular-stapled anastomosis with the trans-oral anvil.| | View in PubMed
- Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.| | View in PubMed
- Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.| | View in PubMed
- Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.| | View in PubMed
- A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells.| | View in PubMed
- Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.| | View in PubMed
- Genomic prognostic models in early-stage lung cancer.| | View in PubMed
- A multi-marker assay to distinguish malignant melanomas from benign nevi.| | View in PubMed
- Respiratory Homeostasis and Exploitation of the Immune System for Lung Cancer Vaccines.| | View in PubMed
- Epidemiology of non-small cell lung cancer in Asian Americans: incidence patterns among six subgroups by nativity.| | View in PubMed
- The role of cancer stem cells in neoplasia of the lung: past, present and future.| | View in PubMed
- Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma.| | View in PubMed
- A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma.| | View in PubMed
- Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung.| | View in PubMed
- Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.| | View in PubMed
- Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription.| | View in PubMed
- mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.| | View in PubMed
- Adjuvant treatment of stage IB NSCLC: the problem of stage subset heterogeneity.| | View in PubMed
- Translational research in glioblastoma multiforme: molecular criteria for patient selection.| | View in PubMed
- Unmet need in lung cancer: can vaccines bridge the gap?| | View in PubMed
- Pharmacogenomic approaches to individualizing chemotherapy for non-small-cell lung cancer: current status and new directions.| | View in PubMed
- Optimal surgical management of Stage I non-small-cell lung cancer in an increasingly aging population: challenges and recent progress.| | View in PubMed
- Epigenetic regulation of RhoB loss of expression in lung cancer.| | View in PubMed
- Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus.| | View in PubMed
- Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.| | View in PubMed
- Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth.| | View in PubMed
- Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.| | View in PubMed
- Roles of secreted frizzled-related proteins in cancer.| | View in PubMed
- Adjuvant chemotherapy of stage I non-small cell lung cancer in North America.| | View in PubMed
- Diagnosis and treatment of bronchioloalveolar carcinoma.| | View in PubMed
- Impact of induction treatment on postoperative complications in the treatment of non-small cell lung cancer.| | View in PubMed
- EGFR expression and mutational analysis as a predictive test.| | View in PubMed
- Natural history of stage I non-small cell lung cancer: implications for early detection.| | View in PubMed
- Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain.| | View in PubMed
- Update on the molecular biology of malignant mesothelioma.| | View in PubMed
- Five-gene signature in non-small-cell lung cancer.| | View in PubMed
- Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth.| | View in PubMed
- Targeting the Wnt signaling pathway to treat Barrett's esophagus.| | View in PubMed
- Wnt inhibitory factor inhibits lung cancer cell growth.| | View in PubMed
- Clinical characteristics and survival of patients with surgically resected, incidentally detected lung cancer.| | View in PubMed
- An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.| | View in PubMed
- Patterns of metastasis in human solid cancers.| | View in PubMed
- Stathmin is overexpressed in malignant mesothelioma.| | View in PubMed
- Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer.| | View in PubMed
- Novel therapies targeting signaling pathways in lung cancer.| | View in PubMed
- Tumor fluoro-2-deoxy-D-glucose avidity on positron emission tomographic scan predicts mortality in patients with early-stage pure and mixed bronchioloalveolar carcinoma.| | View in PubMed
- Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.| | View in PubMed
- Current concepts in bronchioloalveolar carcinoma biology.| | View in PubMed
- Clinical patterns of metastasis.| | View in PubMed
- Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer.| | View in PubMed
- Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database.| | View in PubMed
- Bronchioloalveolar carcinoma: a review.| | View in PubMed
- Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma.| | View in PubMed
- Future directions in the second-line treatment of non-small cell lung cancer.| | View in PubMed
- Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.| | View in PubMed
- Wnt signaling in stem cells and lung cancer.| | View in PubMed
- Wnt-1 signal as a potential cancer therapeutic target.| | View in PubMed
- The role of Wnt signaling in cancer and stem cells.| | View in PubMed
- Wnt2 as a new therapeutic target in malignant pleural mesothelioma.| | View in PubMed
- A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.| | View in PubMed
- Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas.| | View in PubMed
- Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.| | View in PubMed
- Wnt signaling in stem cells and non-small-cell lung cancer.| | View in PubMed
- Efficacy of Wnt-1 monoclonal antibody in sarcoma cells.| | View in PubMed
- Wnt signaling in lung cancer.| | View in PubMed
- Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.| | View in PubMed
- Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus.| | View in PubMed
- Changes in radiographic abnormalities in organ donors: associations with lung transplantation.| | View in PubMed
- Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion.| | View in PubMed
- Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.| | View in PubMed
- Salmonella infection in an anterior mediastinal mass.| | View in PubMed
- Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma.| | View in PubMed
- Cloning and characterization of the promoter of human Wnt inhibitory factor-1.| | View in PubMed
- Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma.| | View in PubMed
- Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.| | View in PubMed
- An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.| | View in PubMed
- Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts.| | View in PubMed
- Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.| | View in PubMed
- Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer.| | View in PubMed
- Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.| | View in PubMed
- Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.| | View in PubMed
- Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer.| | View in PubMed
- Isolated pulmonary arteriovenous malformations requiring anatomic resection.| | View in PubMed
- A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells.| | View in PubMed
- Future directions: oncolytic viruses.| | View in PubMed
- Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET.| | View in PubMed
- Mechanisms of and potential treatment strategies for metastatic disease in non-small cell lung cancer.| | View in PubMed
- Retrocardiac parathyroid tumor: a rare mediastinal site.| | View in PubMed
- SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.| | View in PubMed
- Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression.| | View in PubMed
- Intraoperative radiation therapy in the multimodality approach to upper aerodigestive tract cancer.| | View in PubMed
- Potential of mobile intraoperative radiotherapy technology.| | View in PubMed
- 1st International Lung Cancer Conference in Beijing, October 27-30, 2002.| | View in PubMed
- Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.| | View in PubMed
- Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin.| | View in PubMed
- c-Kit is not expressed in malignant mesothelioma.| | View in PubMed
- Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q.| | View in PubMed
- Malignant mesothelioma does not demonstrate overexpression or gene amplification despite cytoplasmic immunohistochemical staining for c-Erb-B2.| | View in PubMed
- Cloning and characterization of a functional promoter of the human SOCS-3 gene.| | View in PubMed
- Pericardial retraction sutures facilitate intrapericardial pneumonectomy.| | View in PubMed
- A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells.| | View in PubMed
- Emergent surgery for massive pulmonary embolism on the basis of clinical diagnosis.| | View in PubMed
- Contralateral tension pneumothorax during one-lung ventilation for lobectomy: diagnosis aided by fiberoptic bronchoscopy.| | View in PubMed
- Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway.| | View in PubMed
- Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.| | View in PubMed
- Aberrations in the fragile histidine triad (FHIT) gene in idiopathic pulmonary fibrosis.| | View in PubMed
- p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53.| | View in PubMed
- Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.| | View in PubMed
- Stage II (N1) lung cancer.| | View in PubMed
- The impact of changes in radiographic abnormalities in organ donors on successful lung donation.| | View in PubMed
- Expression sequence tag-specific full-length cDNA cloning: actin cDNAs.| | View in PubMed
- Giant tumors of the chest: preoperative embolization and resection.| | View in PubMed
- Positron emission tomography with f18-fluorodeoxyglucose in the staging and preoperative evaluation of malignant pleural mesothelioma.| | View in PubMed
- Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells.| | View in PubMed
- ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.| | View in PubMed
- Pulmonary placental transmogrification: diagnosis and treatment.| | View in PubMed
- Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38.| | View in PubMed
- Giant solitary fibrous tumor of the pleura.| | View in PubMed
- Resection and IORT followed by three-dimensional conformal radiotherapy with or without adjuvant chemotherapy for malignant mesothelioma.| | View in PubMed
- The heimlich device in thoracic surgery.| | View in PubMed
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- IL-2-based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis.| | View in PubMed
- Interleukin-3 induces proliferation but not lymphokine activated killer activity from human and murine mononuclear cells.| | View in PubMed
- Antitumor activity of recombinant interleukin 6 in mice.| | View in PubMed
- In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice.| | View in PubMed
- Metastasectomy for soft tissue sarcoma. Further evidence for efficacy and prognostic indicators.| | View in PubMed
- IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans.| | View in PubMed
- Induction of interferon-beta 2/interleukin-6 (IL-6) by cytokine administration and detection of circulating interleukin-6 in the tumor-bearing state.| | View in PubMed
- Derivation of cells with lytic activity against fresh and cultured tumors from human bone marrow.| | View in PubMed