Biography
Aras N. Mattis, M.D., Ph.D., is a board-certified anatomic pathologist and clinical fellow in the Willenbring Lab. Dr. Mattis trained at the University of Illinois at Urbana-Champaign, earning both his doctorates, Biochemistry and Medicine, there in 2007. He continued his clinical training in Pathology at the University of California San Francisco completing residency in Anatomic Pathology with subsequent fellowship training in Surgical Pathology and Liver and gastrointestinal pathology under his clinical mentor, Dr. Linda Ferrell. Since 2010, he has worked in the Willenbring Lab, investigating the basic mechanisms of liver development and disease in the with a specific focus on liver metabolism and fatty liver disease as well as micro-RNA regulation of liver metabolism.
Education
University of California, Berkeley, B.A., Molecular and Cell Biology, 1998
University of Illinois, Chicago, M.D., Medicine, 2007
University of Illinois, Urbana-Champaign, Ph.D., Biochemistry, 2007
University of California, San Francisco, Anatomic Pathology Resident 2007-2009
University of California, San Francisco, Fellow, Surgical Pathology, 2009-2010
University of California, San Francisco, Fellow, Liver/GI Pathology, 2010-Present
Board Certifications
American Board of Pathology, Anatomic Pathology
Clinical Expertise
Liver and Gastrointestinal Pathology
Program Affiliations
UCSF Department of Pathology
California Institute for Regenerative Medicine
In the News
Research Narrative
Dr. Mattis' postdoctoral work includes the use of translational human biopsy material as well as patient-derived induced pluripotent stem cell reprogramming to hepatocytes. As a long-term goal, this work aims to develop a humanized liver mouse model of fatty liver disease. Aras is supported by the UCSF CIRM clinical fellow training grant and continues to work closely with the UCSF Department of Pathology as a clinical researcher.
Research Interests
Liver diseases including metabolic, pediatric, fibrotic, idiopathic, stem cell derived
Hepatocytes for transplant and disease modeling, micro-RNA regulation of hepatocyte
Development and metabolism, liver and gastrointestinal tumors, site-specific recombination.