University of California San Francisco

Mattis 144.jpg
Aras N. Mattis, M.D., Ph.D.

Assistant Professor, UCSF Department of Pathology

RMB 902D Box 0665

35 Medical Center Way

San Francisco, CA 94143

415.297.7901

[email protected]

    Biography

    Aras N. Mattis, M.D., Ph.D., is a board-certified anatomic pathologist and clinical fellow in the Willenbring Lab. Dr. Mattis trained at the University of Illinois at Urbana-Champaign, earning both his doctorates, Biochemistry and Medicine, there in 2007. He continued his clinical training in Pathology at the University of California San Francisco completing residency in Anatomic Pathology with subsequent fellowship training in Surgical Pathology and Liver and gastrointestinal pathology under his clinical mentor, Dr. Linda Ferrell. Since 2010, he has worked in the Willenbring Lab, investigating the basic mechanisms of liver development and disease in the with a specific focus on liver metabolism and fatty liver disease as well as micro-RNA regulation of liver metabolism.

    Education

    Education

    University of California, Berkeley, B.A., Molecular and Cell Biology, 1998

    University of Illinois, Chicago, M.D., Medicine, 2007

    University of Illinois, Urbana-Champaign, Ph.D., Biochemistry, 2007

    University of California, San Francisco, Anatomic Pathology Resident 2007-2009

    University of California, San Francisco, Fellow, Surgical Pathology, 2009-2010

    University of California, San Francisco, Fellow, Liver/GI Pathology, 2010-Present

    Fellowships

    Board Certifications

    American Board of Pathology, Anatomic Pathology

    Clinical Expertise

    Liver and Gastrointestinal Pathology

    Program Affiliations

    UCSF Department of Pathology

    California Institute for Regenerative Medicine

    Research Narrative

    Dr. Mattis' postdoctoral work includes the use of translational human biopsy material as well as patient-derived induced pluripotent stem cell reprogramming to hepatocytes. As a long-term goal, this work aims to develop a humanized liver mouse model of fatty liver disease. Aras is supported by the UCSF CIRM clinical fellow training grant and continues to work closely with the UCSF Department of Pathology as a clinical researcher.

    Research Interests

    Liver diseases including metabolic, pediatric, fibrotic, idiopathic, stem cell derived

    Hepatocytes for transplant and disease modeling, micro-RNA regulation of hepatocyte

    Development and metabolism, liver and gastrointestinal tumors, site-specific recombination.