Biography
In addition to caring for patients, Posselt conducts research on pancreatic islet cell transplantation, a procedure that can allow people with type 1 diabetes to discontinue insulin therapy. He also investigates mechanisms by which a transplant recipient's body rejects or tolerates tissue from a donor who isn't genetically identical, and he studies the metabolic and biochemical consequences of bariatric surgery.
Posselt earned his medical degree and a doctorate in immunology from the University of Pennsylvania. He completed residencies in internal medicine and general surgery as well as a transplant fellowship at UCSF, before joining the staff in 2003.
Posselt is a member of several professional and honorary societies, and has given presentations on transplant issues related to patient care and research. At UCSF, he supervises residents and fellows in transplant services and general surgery.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of Pennsylvania | PhD | Immunology | 1993 |
University of Pennsylvania | M.D. | School of Medicine | 1993 |
University of California, San Francisco | Residency | Internal Medicine |
Board Certifications
- American Board of Internal Medicine, 1996
- American Board of Surgery, 2002
Clinical Expertise
Bariatric Surgery (Laparoscopic and Open)
Bile Duct Injuries
Bile Duct Strictures
Choledochal Cyst Disease
End-Stage Kidney Disease
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Primary Liver Cancer)
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Liver Cysts
Liver Transplantation
Nonalcoholic Fatty Liver Disease
Pancreas Transplantation
Pediatric Liver Transplantation
Pediatric Kidney Transplantation
Portal Hypertension
Islet Cell Transplantation
Autologous Islet Cell Transplantation
Program Affiliations
Pancreatic Islet Transplantation Program
Bariatric Surgery Center
ABO-Incompatible Kidney Transplant Program
In the News
Grants and Funding
- Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized control | NIH | 2021-07-14 - 2024-05-31 | Role: Co-Principal Investigator
- Treatment of Type I Diabetes by Islet Transplantation into the Gastric Submucosa | NIH | 2014-05-01 - 2021-04-30 | Role: Principal Investigator
- "Advancing Islet Transplant for Type 1 Diabetes Care" | NIH | 2009-09-30 - 2013-07-31 | Role: Principal Investigator
- Effect of Obesity on Long-Term Clinical Outcomes after Kidney Donation | NIH | 2009-09-21 - 2012-06-30 | Role: Principal Investigator
Research Interests
- Transplantation of pancreatic islets as treatment for type 1 diabetes mellitus
- Assessment of long-term clinical outcomes in kidney donors
- Metabolic and biochemical consequences of bariatric surgery
- Clinical outcomes of bariatric surgery in patients with end-stage kidney or liver disease
Publications
- Safety and feasibility of sleeve gastrectomy in morbidly obese patients following liver transplantation.| | PubMed
- Islet Transplantation & β-Cell Replacement Therapies for Diabetes.| | PubMed
- Experience with laparoscopic donor nephrectomy among more than 1000 cases: low complication rates, despite more challenging cases.| | PubMed
- Early and late abdominal bleeding after Roux-en-Y gastric bypass: sources and tailored therapeutic strategies.| | PubMed
- Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.| | PubMed
- Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.| | PubMed
- Clinical islet transplantation at the University of California, San Francisco.| | PubMed
- Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.| | PubMed
- Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review.| | PubMed
- Long-term renal function and cardiovascular disease risk in obese kidney donors.| | PubMed