Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Commitment to Patient Care Award | UCSF | 2012/2013 |
Lifetime Teaching Award | UCSF | 2012/2013 |
Educator of the Year | UCSF | 2009/2010 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of Chicago | M.D. | School of Medicine | 1996 |
Board Certifications
American Board of Radiology
Clinical Expertise
Brain and Spinal Tumors
CyberKnife Irradiation for Lung and Skull Base
Esophageal Cancer
Intensity-modulated radiation therapy (IMRT)
Sarcoma
Stereotactic Lung Radiotherapy (SBRT)
Non-Small Cell Lung Cancer
Small-Cell Lung Cancer
External-beam Radiation
Bronchioloalveolar Carcinoma (BAC)
Clinical Trials
- Related Conditions: Prostate Cancer, Cancer, General, Radiation Toxicity, Sexual Dysfunction| Start Date: | End Date:
- Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer (NCT00750269)Related Conditions: Lung Cancer, Non-Small Cell Lung Cancer, Lung Tumor| Start Date: | End Date:
Program Affiliations
Thoracic Oncology Program
Department of Radiation Oncology
Helen Diller FamilyComprehensive Cancer Center
Sarcoma Program
In the News
Research Narrative
Dr. Gottschalk is involved in a number of clinical research projects. First, he has studied several methods of image-guided radiotherapy (IGRT), including, ultrasound, electronic portal imagining using gold seed fiducial markers and megavoltage cone-beam CT (MVCBCT). His research is one of the first to evaluate prostate bed motion in patients undergoing radiotherapy after prostatectomy. Dr. Gottschalk has investigated the use of MVCBCT for dose calculation and re-calculation as well as a novel high quality, low dose, imaging beam line. The dose re-calculation can be use for dose guided radiation therapy (DGRT).
Second, using the Radiation Oncology clinical database, Dr. Gottschalk has studied: the effectiveness of intraoperative radiation therapy (IORT) in the management of extremity sarcomas and renal cell carcinoma recurrences, permanent seed brachytherapy and high dose-rate brachytherapy (HDR) for the treatment of prostate cancer both as primary therapy and as salvage after radiation failures.
Third, he has been involved as a co-investigator in three trials: a Phase 2, Single-Center, Open-Label phase I/II study to evaluate safety and efficacy and Safety in patients who have resectable esophageal cancer and are treated with neoadjuvant cisplatin, irinotecan (CPT-11), ZD1839 (IRESSA®), and radiotherapy followed by surgical resection; a phase II study of radiation therapy, paclitaxel poliglumex and carboplatin in stage III non-small cell lung cancer; and a phase I/II open-label dose escalation study of anti-CTLA4 antibody with radiation for metastatic hormone refractory prostate cancer.
Forth, Dr. Gottschalk is involved with several RTOG (Radiation Therapy Oncology Group) studies. These have included several prostate cancer trials that investigate: high-dose vs standard-dose readiation for intermediate-risk prostate cancer; brachytherapy vs external-beam radiation plus brachytherapy for intermediate-risk prostate cancer; and standard fractionation vs hypofractionation for low-risk prostate cancer. Finally, as Director of the CyberKnife Radiosurgery Program Dr. Gottschalk oversees several of the stereotactic body radiosugery (SBRT) trials for lung and prostate cancer. He has a particular interest in the use of CyberKnife SBRT for the treatment of prostate cancer, kidney cancer, and lung cancer.
Research Interests
- Radiation in combination with chemotherapy and targeted agents
- Image-guided and adaptive radiation therapy
- Radiation sensitizers and protectors
Publications
- Deep match: A zero-shot framework for improved fiducial-free respiratory motion tracking.| | View in PubMed
- Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel.| | View in PubMed
- All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals.| | View in PubMed
- Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles.| | View in PubMed
- WormRuler: A software to track body length used to characterize a super red-shifted channelrhodopsin in Caenorhabditis elegans.| | View in PubMed
- Addition of Enzalutamide to Leuprolide and Definitive Radiation Therapy Is Tolerable and Effective in High-Risk Localized or Regional Nonmetastatic Prostate Cancer: Results From a Phase 2 Trial.| | View in PubMed
- Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior.| | View in PubMed
- Photoactivated Adenylyl Cyclases as Optogenetic Modulators of Neuronal Activity.| | View in PubMed
- BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons.| | View in PubMed
- Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide-gated channels.| | View in PubMed
- Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.| | View in PubMed
- Stereotactic Body Radiation Therapy and High-Dose-Rate Brachytherapy Boost in Combination With Intensity Modulated Radiation Therapy for Localized Prostate Cancer: A Single-Institution Propensity Score Matched Analysis.| | View in PubMed
- Evaluation of a National Comprehensive Cancer Network Guidelines-Based Decision Support Tool in Patients With Non-Small Cell Lung Cancer: A Nonrandomized Clinical Trial.| | View in PubMed
- Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans.| | View in PubMed
- Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.| | View in PubMed
- Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit.| | View in PubMed
- Rhodopsin-based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans.| | View in PubMed
- Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans.| | View in PubMed
- Dedicated Diagnostic Radiology/Radiation Oncology Rounds: Added Value Beyond Traditional Tumor Boards.| | View in PubMed
- A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission.| | View in PubMed
- Impact of Staging 68Ga-PSMA-11 PET Scans on Radiation Treatment Plansin Patients With Prostate Cancer.| | View in PubMed
- Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network.| | View in PubMed
- Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins.| | View in PubMed
- Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans.| | View in PubMed
- Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.| | View in PubMed
- Endophilin A and B Join Forces With Clathrin to Mediate Synaptic Vesicle Recycling in Caenorhabditis elegans.| | View in PubMed
- Influence of respiratory motion management technique on radiation pneumonitis risk with robotic stereotactic body radiation therapy.| | View in PubMed
- Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans.| | View in PubMed
- An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations.| | View in PubMed
- ACR Appropriateness Criteria for external beam radiation therapy treatment planning for clinically localized prostate cancer, part II of II.| | View in PubMed
- ACR Appropriateness Criteria® Locally Advanced, High-Risk Prostate Cancer.| | View in PubMed
- Respiration-Induced Intraorgan Deformation of the Liver: Implications for Treatment Planning in Patients Treated With Fiducial Tracking.| | View in PubMed
- ACR appropriateness criteria: Permanent source brachytherapy for prostate cancer.| | View in PubMed
- ACR Appropriateness Criteria® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II.| | View in PubMed
- Correction: Endoscopic Gold Fiducial Marker Placement into the Bladder Wall to Optimize Radiotherapy Targeting for Bladder-Preserving Management of Muscle-Invasive Bladder Cancer: Feasibility and Initial Outcomes.| | View in PubMed
- Hybrid minimally invasive Ivor Lewis esophagectomy after neoadjuvant chemoradiation yields excellent long-term survival outcomes with minimal morbidity.| | View in PubMed
- Photoswitchable diacylglycerols enable optical control of protein kinase C.| | View in PubMed
- Receiver operating curves and dose-volume analysis of late toxicity with stereotactic body radiation therapy for prostate cancer.| | View in PubMed
- Interfraction Anatomical Variability Can Lead to Significantly Increased Rectal Dose for Patients Undergoing Stereotactic Body Radiotherapy for Prostate Cancer.| | View in PubMed
- Long-term Outcomes Following Radiation Therapy For Prostate Cancer Patients With Lymph Node Metastases at Diagnosis Treated With and Without Surgery.| | View in PubMed
- An Evaluation of Robotic and Conventional IMRT for Prostate Cancer: Potential for Dose Escalation.| | View in PubMed
- Outcomes of hypofractionated stereotactic body radiotherapy boost for intermediate and high-risk prostate cancer.| | View in PubMed
- Arrhythmogenic effects of mutated L-type Ca 2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans.| | View in PubMed
- Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients.| | View in PubMed
- Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp.| | View in PubMed
- Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma.| | View in PubMed
- Patient- and treatment-specific predictors of genitourinary function after high-dose-rate monotherapy for favorable prostate cancer.| | View in PubMed
- Obesity in regional anesthesia--a risk factor for peripheral catheter-related infections.| | View in PubMed
- AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks.| | View in PubMed
- Dose-volume analysis and the temporal nature of toxicity with stereotactic body radiation therapy for prostate cancer.| | View in PubMed
- Comparison between target margins derived from 4DCT scans and real-time tumor motion tracking: insights from lung tumor patients treated with robotic radiosurgery.| | View in PubMed
- Erratum: Synthetic retinal analogs modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.| | View in PubMed
- A consistent muscle activation strategy underlies crawling and swimming in Caenorhabditis elegans.| | View in PubMed
- Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior.| | View in PubMed
- Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.| | View in PubMed
- ACR appropriateness Criteria® Postradical prostatectomy irradiation in prostate cancer.| | View in PubMed
- Analysis of dose distribution and risk of pneumonitis in stereotactic body radiation therapy for centrally located lung tumors: a comparison of robotic radiosurgery, helical tomotherapy and volumetric modulated arc therapy.| | View in PubMed
- [Differences of analgesic efficacy and complication rates between ultrasound and nervestimulator guided peripheral nerve catheters : Database analysis on patient-relevant target parameters].| | View in PubMed
- Pre-plan parameters predict post-implant D90 ≥ 140 Gy for (125)I permanent prostate implants.| | View in PubMed
- ACR Appropriateness Criteria® Definitive External-Beam Irradiation in stage T1 and T2 prostate cancer.| | View in PubMed
- Response to Drs Rogers, Hayes, and Demanes.| | View in PubMed
- Commentary on "A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma." Siva S, Pham D, Gill S, Corcoran NM, Foroudi F. Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Victoria, Austral| | View in PubMed
- Commentary on "Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer." Gray PJ, Paly JJ, Yeap BY, Sanda MG, Sandler HM, Michalski JM, Talcott JA, Coen JJ, Hamstra DA, Shiple| | View in PubMed
- Commentary on "Toxicity after external beam radiotherapy for prostate cancer: an analysis of late morbidity in men with diabetes mellitus." Kalakota K, Liauw SL, Department of Radiation Oncology, Northwestern Memorial Hospital, Chicago, IL.: Urology 2013;| | View in PubMed
- The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up.| | View in PubMed
- Endoscopic gold fiducial marker placement into the bladder wall to optimize radiotherapy targeting for bladder-preserving management of muscle-invasive bladder cancer: feasibility and initial outcomes.| | View in PubMed
- Hypofractionated SBRT versus conventionally fractionated EBRT for prostate cancer: comparison of PSA slope and nadir.| | View in PubMed
- Commentary on "secondary cancers after intensity-modulated radiotherapy, brachytherapy, and radical prostatectomy for the treatment of prostate cancer: incidence and cause-specific survival outcomes according to the initial treatment intervention." Zelefs| | View in PubMed
- Evaluation of ray tracing and Monte Carlo algorithms in dose calculation and clinical outcomes for robotic stereotactic body radiotherapy of lung cancers.| | View in PubMed
- Photoactivated adenylyl cyclases as optogenetic modulators of neuronal activity.| | View in PubMed
- ACR Appropriateness Criteria high-dose-rate brachytherapy for prostate cancer.| | View in PubMed
- Cold spot mapping inferred from MRI at time of failure predicts biopsy-proven local failure after permanent seed brachytherapy in prostate cancer patients: implications for focal salvage brachytherapy.| | View in PubMed
- Improving plan quality and consistency by standardization of dose constraints in prostate cancer patients treated with CyberKnife.| | View in PubMed
- Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization.| | View in PubMed
- In vivo synaptic recovery following optogenetic hyperstimulation.| | View in PubMed
- Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behaviour.| | View in PubMed
- Salvage HDR brachytherapy for recurrent prostate cancer after previous definitive radiation therapy: 5-year outcomes.| | View in PubMed
- Keeping track of worm trackers.| | View in PubMed
- ACR Appropriateness Criteria prostate cancer--pretreatment detection, staging, and surveillance.| | View in PubMed
- Computer-assisted, atlas-based segmentation for target volume delineation in whole pelvic IMRT for prostate cancer.| | View in PubMed
- Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans.| | View in PubMed
- Can regional anaesthesia for lymph-node dissection improve the prognosis in malignant melanoma?| | View in PubMed
- Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer.| | View in PubMed
- Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors.| | View in PubMed
- Temporal compartmental dosing effects for robotic prostate stereotactic body radiotherapy.| | View in PubMed
- Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.| | View in PubMed
- PACα--an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans.| | View in PubMed
- Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans.| | View in PubMed
- Stereotactic body radiotherapy as monotherapy or post-external beam radiotherapy boost for prostate cancer: technique, early toxicity, and PSA response.| | View in PubMed
- Controversies in diagnosis of pulmonary embolism.| | View in PubMed
- High-dose-rate brachytherapy boost for prostate cancer: comparison of two different fractionation schemes.| | View in PubMed
- Patellar metastatic melanoma in a 13-year-old boy.| | View in PubMed
- Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III).| | View in PubMed
- Comparison of patient megavoltage cone beam CT images acquired with an unflattened beam from a carbon target and a flattened treatment beam.| | View in PubMed
- A diamond target for megavoltage cone-beam CT.| | View in PubMed
- Dose gradient near target-normal structure interface for nonisocentric CyberKnife and isocentric intensity-modulated body radiotherapy for prostate cancer.| | View in PubMed
- Equivalent biochemical control and improved prostate-specific antigen nadir after permanent prostate seed implant brachytherapy versus high-dose three-dimensional conformal radiotherapy and high-dose conformal proton beam radiotherapy boost.| | View in PubMed
- [Pain and quality of life for living donors after nephrectomy].| | View in PubMed
- Nonrandom intrafraction target motions and general strategy for correction of spine stereotactic body radiotherapy.| | View in PubMed
- High-dose-rate brachytherapy for localized prostate adenocarcinoma post abdominoperineal resection of the rectum and pelvic irradiation: Technique and experience.| | View in PubMed
- Dose recalculation and the Dose-Guided Radiation Therapy (DGRT) process using megavoltage cone-beam CT.| | View in PubMed
- Salvage permanent perineal radioactive-seed implantation for treating recurrence of localized prostate adenocarcinoma after external beam radiotherapy.| | View in PubMed
- Correction of megavoltage cone-beam CT images of the pelvic region based on phantom measurements for dose calculation purposes.| | View in PubMed
- Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans.| | View in PubMed
- Simulated real time image guided intrafraction tracking-delivery for hypofractionated prostate IMRT.| | View in PubMed
- Sci-Thurs PM: Delivery-12: Correction and calibration of megavoltage cone-beam CT images for the calculation of the dose of the day.| | View in PubMed
- Proposed rectal dose constraints for patients undergoing definitive whole pelvic radiotherapy for clinically localized prostate cancer.| | View in PubMed
- Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II.| | View in PubMed
- Very low probability interpretation of V/Q lung scans in combination with low probability objective clinical assessment reliably excludes pulmonary embolism: data from PIOPED II.| | View in PubMed
- Patient dose considerations for routine megavoltage cone-beam CT imaging.| | View in PubMed
- Usefulness of multidetector spiral computed tomography according to age and gender for diagnosis of acute pulmonary embolism.| | View in PubMed
- Daily electronic portal imaging of implanted gold seed fiducials in patients undergoing radiotherapy after radical prostatectomy.| | View in PubMed
- Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II Investigators.| | View in PubMed
- Feasibility of high-dose-rate brachytherapy salvage for local prostate cancer recurrence after radiotherapy: the University of California-San Francisco experience.| | View in PubMed
- Comparative study of different concentrations of prilocaine and ropivacaine for intraoperative axillary brachial plexus block.| | View in PubMed
- Clinical outcomes of intraoperative radiation therapy for extremity sarcomas.| | View in PubMed
- Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism.| | View in PubMed
- [Infratentorial progressive multifocal leukoencephalopathy in a patient with pulmonary sarcoidosis].| | View in PubMed
- Management of isolated renal fossa recurrence following radical nephrectomy.| | View in PubMed
- Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.| | View in PubMed
- PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.| | View in PubMed
- Combined modality treatment with high-dose-rate brachytherapy boost for locally advanced prostate cancer.| | View in PubMed
- High-resolution dental magnetic resonance imaging of inferior alveolar nerve responses to the extraction of third molars.| | View in PubMed
- The use of hormonal therapy with radiotherapy for prostate cancer: analysis of prospective randomised trials.| | View in PubMed
- eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx.| | View in PubMed
- Evaluation of ultrasound-based prostate localization for image-guided radiotherapy.| | View in PubMed
- Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.| | View in PubMed
- Bell's palsy: what is the prognostic value of measurements of signal intensity increases with contrast enhancement on MRI?| | View in PubMed
- Chronic alcohol consumption and cerebral indices of oxidative stress: is there a link?| | View in PubMed
- p27Kip1 is required for PTEN-induced G1 growth arrest.| | View in PubMed
- Loss of PTEN facilitates HIF-1-mediated gene expression.| | View in PubMed
- Mapping of secondary somatosensory cortex activation induced by vibrational stimulation: an fMRI study.| | View in PubMed
- Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL.| | View in PubMed
- Elderly Patients With no Prior Cardiopulmonary Disease Show Ventilation/Perfusion Lung Scan Characteristics That Are Sensitive and Specific for Pulmonary Embolism.| | View in PubMed
- Pulmonary embolism among patients with a nearly normal ventilation/perfusion lung scan.| | View in PubMed
- Small perfusion defects in suspected pulmonary embolism.| | View in PubMed
- Evaluation of individual criteria for low probability interpretation of ventilation-perfusion lung scans.| | View in PubMed
- Scintigraphic lung scans and clinical assessment in critically ill patients with suspected acute pulmonary embolism.| | View in PubMed
- Apoptosis in B lymphocytes: the WEHI-231 perspective.| | View in PubMed
- Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.| | View in PubMed
- Critical review of ventilation/perfusion lung scans in acute pulmonary embolism.| | View in PubMed
- Mechanisms of ventilatory periodicities.| | View in PubMed
- Value of ventilation/perfusion scans versus perfusion scans alone in acute pulmonary embolism.| | View in PubMed
- Correlation between oscillations in ventilation and frequency content of the electroencephalogram.| | View in PubMed
- Diagnosis of acute pulmonary embolism in the elderly.| | View in PubMed
- Usefulness of noninvasive diagnostic tools for diagnosis of acute pulmonary embolism in patients with a normal chest radiograph.| | View in PubMed
- Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance.| | View in PubMed
- Tomographic gallium-67 citrate scanning. Useful new surveillance for metastatic melanoma.| | View in PubMed
- Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma.| | View in PubMed
- Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography.| | View in PubMed
- Scintigraphic evaluation of lymphoma: a comparative study of 67Ga-citrate and 111In-Bleomycin.| | View in PubMed
- The scintillation camera with diverging collimator: physical parameters and a clinical evaluation.| | View in PubMed
- A COMPARISON OF RESULTS OF BRAIN SCANNING USING GA68-EDTA AND THE POSITRON SCINTILLATION CAMERA, WITH HG203-NEOHYDRIN AND THE CONVENTIONAL FOCUSED COLLIMATOR SCANNER.| | View in PubMed
- RELATIVE EFFICIENCY OF HIGH-LET RADIATION (BRAGG-PEAK LITHIUM IONS) ON NORMAL RABBIT SKIN, USING INTEGRAL DOSE AS A BASIS FOR COMPARISON.| | View in PubMed
- THE SENSITIVITY OF THE POSITRON SCINTILLATION CAMERA FOR DETECTING SIMULATED BRAIN TUMORS WITH GALLIUM 68-EDTA.| | View in PubMed